Someone at work played this prank on a business analyst and almost got fired. It was the early 90's, and we were a shop running HP/UX on Apollo workstations. She was a SME for the application we were developing, but was otherwise non-technical. He and her were friends, so one day he fired up xroach on her system. When she moved a window she absolutely freaked out, and wanted the guy fired. He kept his job, but I don't think they were friends after that.
Plenty of people in this thread with Apollos in their past. We had no fun on the Apollos in college; they ran DOMAIN/OS, I programmed the 68xxx assembly and I got out of there.
I did all my mischief on the Unix machines: 3B2s with dumb terminals, and diskless SPARCstation SLCs.