Almost every significant character in the recent limited series Cyberpunk: Edgerunners was a Frankenstein's monster and there were multiple doctor Frankensteins, some corporate and some freelance, competing against each other.
I disagree: Frankenstein's monster is new life bereft of history or precedent, as opposed to a regular man converted into strangeness and exiled by acquired differences.
Most of those cyborg stories (Edgerunners, the newer Deus Ex's games, Ghost In The Shell) are more like... Hmm, perhaps Phantom of the Opera.
That's true for Project 2501, but not the cyborg protagonists of Section 9. They aren't Frankenstein's monsters, especially not in a society where some degree of augmentation is so normal.
That includes Motoko Kusanagi--even when it's been hinted she has relied on artificial bodies since childhood, that's still a very human form of alienation.
Agree on that, but my point is still that GitS isn't a good example because cybernetics are there because of setting, not necessary the "modern Prometheus" thingy.
GiTS creator Masamune Shirow's earlier works also feature androids or other sorts of synthetic life. Particularly Buaku's gang and Crolis in Dominion, and the military androids in Black Magic M-66.