I envision an inflected grammar. That sounds crazy I know, but x64 is an inflected language already. The pointer arithmetic you can attach to a register isn't an expression or a distinct group of words, it's a suffix. Part of the word, indistinguishable from it. Someone once did a great job of explaining to me how that mapped to microcode in a shockingly static way and it blew my mind. I see affixes for controlling the branch predictor. Operations should also be inflected in a contextual way, making their relationship to other operations explicit, giving you control over how things are pipelined. Maybe take some inspiration from afro-asiatic languages, use kind of consonantal root system.

The end result would look nothing like any other programming language and would die in obscurity, to be honest. But holy shit it would be really fucking cool.