Oh yes there is. He and She can only refer to people while They can refer to things, too. Take for example: "if a person wishes to rungle the querts, they need to configure them such so that they will be in the state indicated by the widget manager". A sentence like that, while ultimately understandable, does cause me mild confusion at first read, and I'm sure I can come up with a more natural-sounding, but more confusing example, if I weren't so tired.
From my point of view, English is basically fucked. You've ended up with third person pronouns that are irredeemably connected with the gender of the person they describe. They is really a cludge that sort of works, but isn't quite a drop-in replacement for good old She and He.
I'd use They when the text can flow naturally with it, but drop to She/He when it starts sounding ambiguous or use any other kind of description. If writing instruction manuals, I'd use You to refer to the user at all times, or just drop to passive form and not mention people's genders at all.
From my point of view, English is basically fucked. You've ended up with third person pronouns that are irredeemably connected with the gender of the person they describe. They is really a cludge that sort of works, but isn't quite a drop-in replacement for good old She and He.
I'd use They when the text can flow naturally with it, but drop to She/He when it starts sounding ambiguous or use any other kind of description. If writing instruction manuals, I'd use You to refer to the user at all times, or just drop to passive form and not mention people's genders at all.